The Chiefs don't have very many legitimate weapons on offense but the obvious big two are Bowe and Charles. I think they are 3rd in the league in rushing but their passing is just beyond bad because Cassell is hardly anything to write home about; 25th overall in the league.
Do you just put Ike on Bowe and focus all the rest of your efforts on the run game?
Just have to be careful in this one, if you play the way you're capable of then you should win pretty easily. If you think even for a second that this is a walk in the park then we're in trouble because we play down to our competition way too often as we all know.